- Identifier
- DBSNPE000132, DBSNPE005980
- Drug
- Metoprolol (DB00264)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
- Allele Name
- CYP2D6*4
- Genotype(s)
- (A;A)
- Type(s)
- Directly Studied Effect
- Groups
- Non-functional CYP2D6
- Description
- Patients with this genotype have reduced metabolism of metoprolol.
- References
- Bijl MJ, Visser LE, van Schaik RH, Kors JA, Witteman JC, Hofman A, Vulto AG, van Gelder T, Stricker BH: Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Clin Pharmacol Ther. 2009 Jan;85(1):45-50. doi: 10.1038/clpt.2008.172. Epub 2008 Sep 10. [Article]