Pharmacogenomic Effect/ADR for Metoprolol (DBSNPE000132)

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Identifier
DBSNPE000132, DBSNPE005980
Drug
Metoprolol (DB00264)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
A allelers3892097
Allele Name
CYP2D6*4
Genotype(s)
(A;A)
Type(s)
Directly Studied Effect
Groups
Non-functional CYP2D6
Description
Patients with this genotype have reduced metabolism of metoprolol.
References
  1. Bijl MJ, Visser LE, van Schaik RH, Kors JA, Witteman JC, Hofman A, Vulto AG, van Gelder T, Stricker BH: Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Clin Pharmacol Ther. 2009 Jan;85(1):45-50. doi: 10.1038/clpt.2008.172. Epub 2008 Sep 10. [Article]