Pharmacogenomic Effect/ADR for Cisplatin (DBSNPE000137)

Identifier
DBSNPE000137
Drug
Cisplatin (DB00515)
Interacting Gene/Enzyme
DNA repair protein complementing XP-C cells
Gene Name
XPC
UniProt ID
Q01831
Defining Change(s)
Allele Name
Not Available
Genotype(s)
(C;C)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of ototoxicity with [durg: cisplatin].
References
  1. Sakano S, Hinoda Y, Sasaki M, Wada T, Matsumoto H, Eguchi S, Shinohara A, Kawai Y, Hara T, Nagao K, Hara T, Naito K, Matsuyama H: Nucleotide excision repair gene polymorphisms may predict acute toxicity in patients treated with chemoradiotherapy for bladder cancer. Pharmacogenomics. 2010 Oct;11(10):1377-87. doi: 10.2217/pgs.10.106. [Article]