Pharmacogenomic Effect/ADR for Cyclophosphamide (DBSNPE000141)

Identifier
DBSNPE000141
Drug
Cyclophosphamide (DB00531)
Interacting Gene/Enzyme
Cytochrome P450 3A4
Gene Name
CYP3A4
UniProt ID
P08684
Defining Change(s)
G Allellers2740574
Allele Name
CYP3A4*1B
Genotype(s)
(A;G) / (G;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced metabolism of cyclophosphamide to its active form and reduced disease free survival time when using cyclophosphamide to treat node-positive breast cancer.
References
  1. Gor PP, Su HI, Gray RJ, Gimotty PA, Horn M, Aplenc R, Vaughan WP, Tallman MS, Rebbeck TR, DeMichele A: Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study. Breast Cancer Res. 2010;12(3):R26. doi: 10.1186/bcr2570. Epub 2010 May 10. [Article]