- Identifier
- DBSNPE000141
- Drug
- Cyclophosphamide (DB00531)
- Interacting Gene/Enzyme
- Cytochrome P450 3A4
- Gene Name
- CYP3A4
- UniProt ID
- P08684
- Defining Change(s)
- Allele Name
- CYP3A4*1B
- Genotype(s)
- (A;G) / (G;G)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have reduced metabolism of cyclophosphamide to its active form and reduced disease free survival time when using cyclophosphamide to treat node-positive breast cancer.
- References
- Gor PP, Su HI, Gray RJ, Gimotty PA, Horn M, Aplenc R, Vaughan WP, Tallman MS, Rebbeck TR, DeMichele A: Cyclophosphamide-metabolizing enzyme polymorphisms and survival outcomes after adjuvant chemotherapy for node-positive breast cancer: a retrospective cohort study. Breast Cancer Res. 2010;12(3):R26. doi: 10.1186/bcr2570. Epub 2010 May 10. [Article]