Pharmacogenomic Effect/ADR for Cyclophosphamide (DBSNPE000142)

Identifier
DBSNPE000142
Drug
Cyclophosphamide (DB00531)
Interacting Gene/Enzyme
Cytochrome P450 2B6
Gene Name
CYP2B6
UniProt ID
P20813
Defining Change(s)
C Allellers4802101
Allele Name
CYP2B6*1G
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced metabolism of cyclophosphamide to its active form.
References
  1. Nakajima M, Komagata S, Fujiki Y, Kanada Y, Ebi H, Itoh K, Mukai H, Yokoi T, Minami H: Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients. Pharmacogenet Genomics. 2007 Jun;17(6):431-45. [Article]