Pharmacogenomic Effect/ADR for Olanzapine (DBSNPE000146)

Identifier
DBSNPE000146
Drug
Olanzapine (DB00334)
Interacting Gene/Enzyme
5-hydroxytryptamine receptor 1A
Gene Name
HTR1A
UniProt ID
P08908
Defining Change(s)
CC Allele (homozygous)rs6295
Allele Name
Not Available
Genotype(s)
(C;C)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
The presence of this polymorphism in HTR1A may indicate a higher level of efficacy in improving negative symptoms of schizophrenia when treated with olanzapine.
References
  1. Sumiyoshi T, Tsunoda M, Higuchi Y, Itoh T, Seo T, Itoh H, Suzuki M, Kurachi M: Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia. Adv Ther. 2010 May;27(5):307-13. doi: 10.1007/s12325-010-0035-4. Epub 2010 Jun 8. [Article]