- Identifier
- DBSNPE000146
- Drug
- Olanzapine (DB00334)
- Interacting Gene/Enzyme
- 5-hydroxytryptamine receptor 1A
- Gene Name
- HTR1A
- UniProt ID
- P08908
- Defining Change(s)
- Allele Name
- Not Available
- Genotype(s)
- (C;C)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- The presence of this polymorphism in HTR1A may indicate a higher level of efficacy in improving negative symptoms of schizophrenia when treated with olanzapine.
- References
- Sumiyoshi T, Tsunoda M, Higuchi Y, Itoh T, Seo T, Itoh H, Suzuki M, Kurachi M: Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia. Adv Ther. 2010 May;27(5):307-13. doi: 10.1007/s12325-010-0035-4. Epub 2010 Jun 8. [Article]