- Identifier
- DBSNPE000150
- Drug
- Acetylsalicylic acid (DB00945)
- Interacting Gene/Enzyme
- Integrin beta-3
- Gene Name
- ITGB3
- UniProt ID
- P05106
- Defining Change(s)
- Allele Name
- GPIIIa PlA2
- Genotype(s)
- (C;C) / (C;T)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have increased resistance to the anti-thrombotic effects of aspirin.
- References
- Undas A, Brummel K, Musial J, Mann KG, Szczeklik A: Pl(A2) polymorphism of beta(3) integrins is associated with enhanced thrombin generation and impaired antithrombotic action of aspirin at the site of microvascular injury. Circulation. 2001 Nov 27;104(22):2666-72. [Article]