Pharmacogenomic Effect/ADR for Infliximab (DBSNPE000152)
- Identifier
- DBSNPE000152
- Drug
- Infliximab (DB00065)
- Interacting Gene/Enzyme
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Gene Name
- FCGR3A
- UniProt ID
- P08637
- Defining Change(s)
CC Allele (homozygous) rs1801274 - Allele Name
- Not Available
- Genotype(s)
- (C;C)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have increased ACR20 response when using infliximab to treat rheumatoid arthritis.
- References
- Canete JD, Suarez B, Hernandez MV, Sanmarti R, Rego I, Celis R, Moll C, Pinto JA, Blanco FJ, Lozano F: Influence of variants of Fc gamma receptors IIA and IIIA on the American College of Rheumatology and European League Against Rheumatism responses to anti-tumour necrosis factor alpha therapy in rheumatoid arthritis. Ann Rheum Dis. 2009 Oct;68(10):1547-52. doi: 10.1136/ard.2008.096982. Epub 2008 Oct 17. [Article]