- Identifier
- DBSNPE000153
- Drug
- Cetuximab (DB00002)
- Interacting Gene/Enzyme
- Low affinity immunoglobulin gamma Fc region receptor II-a
- Gene Name
- FCGR2A
- UniProt ID
- P12318
- Defining Change(s)
- Allele Name
- Not Available
- Genotype(s)
- (C;T) / (T;T)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype may have increased progression-free survival time when using cetuximab to treat colorectal cancer.
- References
- Zhang W, Gordon M, Schultheis AM, Yang DY, Nagashima F, Azuma M, Chang HM, Borucka E, Lurje G, Sherrod AE, Iqbal S, Groshen S, Lenz HJ: FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol. 2007 Aug 20;25(24):3712-8. [Article]