Pharmacogenomic Effect/ADR for Modafinil (DBSNPE000154)

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Identifier
DBSNPE000154
Drug
Modafinil (DB00745)
Interacting Gene/Enzyme
Catechol O-methyltransferase
Gene Name
COMT
UniProt ID
P21964
Defining Change(s)
AA allelers4680
Allele Name
Not Available
Genotype(s)
(A;A)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced improvement in vigor and well-being with modafinil.
References
  1. Bodenmann S, Xu S, Luhmann UF, Arand M, Berger W, Jung HH, Landolt HP: Pharmacogenetics of modafinil after sleep loss: catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther. 2009 Mar;85(3):296-304. doi: 10.1038/clpt.2008.222. Epub 2008 Nov 26. [Article]