- Identifier
- DBSNPE000160
- Drug
- Rituximab (DB00073)
- Interacting Gene/Enzyme
- Low affinity immunoglobulin gamma Fc region receptor III-A
- Gene Name
- FCGR3A
- UniProt ID
- P08637
- Defining Change(s)
- Allele Name
- FCGR3A
- Genotype(s)
- (G;G) / (G;T)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype have increased frequency of anti-tumor response when using rituximab to treat diffuse large B-cell lymphoma, follicular lymphoma, or [follicular non-Hodgkin lymphoma].
- References
- Kim DH, Jung HD, Kim JG, Lee JJ, Yang DH, Park YH, Do YR, Shin HJ, Kim MK, Hyun MS, Sohn SK: FCGR3A gene polymorphisms may correlate with response to frontline R-CHOP therapy for diffuse large B-cell lymphoma. Blood. 2006 Oct 15;108(8):2720-5. Epub 2006 Apr 11. [PubMed:16609067]