Pharmacogenomic Effect/ADR for Carbamazepine (DBSNPE000172)

Identifier
DBSNPE000172, DBSNPE000180
Drug
Carbamazepine (DB00564)
Interacting Gene/Enzyme
Flotillin-1
Gene Name
FLOT1
UniProt ID
O75955
Defining Change(s)
G > Crs3909184
G > Crs3909184
Allele Name
HLA-B*1502
Genotype(s)
(C;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Taiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine.
References
  1. Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT: Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486. [Article]