Pharmacogenomic Effect/ADR for Carbamazepine (DBSNPE000173)

Identifier
DBSNPE000173, DBSNPE000181
Drug
Carbamazepine (DB00564)
Interacting Gene/Enzyme
Mucin-21
Gene Name
MUC21
UniProt ID
Q5SSG8
Defining Change(s)
G>Ars2844682
G>Ars2844682
Allele Name
HLA-B*1502
Genotype(s)
(A;G) / (G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Taiwanese, Chinese, Indians, and Chinese–American patients with this genotype have increased risk of Stevens-Johnson syndrome or toxic epidermal necrolysis with carbamazepine.
References
  1. Chung WH, Hung SI, Hong HS, Hsih MS, Yang LC, Ho HC, Wu JY, Chen YT: Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486. [Article]