Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE000184)

Identifier
DBSNPE000184
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
T > Crs41291556
Allele Name
CYP2C19*8
Genotype(s)
(C;C) / (C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have reduced metabolism of mephenytoin.
References
  1. Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [Article]