Pharmacogenomic Effect/ADR for Lansoprazole (DBSNPE000206)

Identifier
DBSNPE000206
Drug
Lansoprazole (DB00448)
Interacting Gene/Enzyme
Multidrug resistance protein 1
Gene Name
ABCB1
UniProt ID
P08183
Defining Change(s)
C Allele, heterozygoters1045642
Allele Name
Not Available
Genotype(s)
(C;T)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased plasma concentration of lansoprazole.
References
  1. Miura M, Satoh S, Tada H, Saito M, Kagaya H, Inoue K, Sagae Y, Kanno S, Ishikawa M, Habuchi T, Suzuki T: Influence of ABCB1 C3435T polymorphism on the pharmacokinetics of lansoprazole and gastroesophageal symptoms in Japanese renal transplant recipients classified as CYP2C19 extensive metabolizers and treated with tacrolimus. Int J Clin Pharmacol Ther. 2006 Dec;44(12):605-13. [Article]