Pharmacogenomic Effect/ADR for Tegafur (DBSNPE000227)
- Identifier
- DBSNPE000227, DBSNPE006025
- Drug
- Tegafur (DB09256)
- Interacting Gene/Enzyme
- Dihydropyrimidine dehydrogenase [NADP(+)]
- Gene Name
- DPYD
- UniProt ID
- Q12882
- Defining Change(s)
T > A rs67376798 - Allele Name
- Not Available
- Genotype(s)
- (A;A) / (A;T)
- Type(s)
- ADR Directly Studied
- Groups
- Not Available
- Description
- The presence of this genotype in DPYD may be associated with an increased risk of drug-related toxicity from tegafur therapy.
- References
- Caudle KE, Thorn CF, Klein TE, Swen JJ, McLeod HL, Diasio RB, Schwab M: Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing. Clin Pharmacol Ther. 2013 Dec;94(6):640-5. doi: 10.1038/clpt.2013.172. Epub 2013 Aug 29. [Article]