Pharmacogenomic Effect/ADR for Tacrolimus (DBSNPE000243)
- Identifier
- DBSNPE000243
- Drug
- Tacrolimus (DB00864)
- Interacting Gene/Enzyme
- Cytochrome P450 3A5
- Gene Name
- CYP3A5
- UniProt ID
- P20815
- Defining Change(s)
Functional gene Not Available - Allele Name
- CYP3A5*1
- Genotype(s)
- Not Available
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype in CYP3A5 are extensive metabolizers and require higer doses of tacrolimus to attain the therapeutic effect.
- References
- Birdwell KA, Decker B, Barbarino JM, Peterson JF, Stein CM, Sadee W, Wang D, Vinks AA, He Y, Swen JJ, Leeder JS, van Schaik R, Thummel KE, Klein TE, Caudle KE, MacPhee IA: Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing. Clin Pharmacol Ther. 2015 Jul;98(1):19-24. doi: 10.1002/cpt.113. Epub 2015 Jun 3. [Article]