Pharmacogenomic Effect/ADR for Warfarin (DBSNPE000253)
- Identifier
- DBSNPE000253
- Drug
- Warfarin (DB00682)
- Interacting Gene/Enzyme
- Phylloquinone omega-hydroxylase CYP4F2
- Gene Name
- CYP4F2
- UniProt ID
- P78329
- Defining Change(s)
T Allele, homozygous rs2108622 - Allele Name
- Not Available
- Genotype(s)
- (T;T)
- Type(s)
- Effect Directly Studied
- Groups
- Not Available
- Description
- Patients with this genotype in CP4F2 may require higer doses of warfarin to attain therapeutic anticoagulant activity.
- References
- Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, Lee MT, Gage BF, Kimmel SE, Perera MA, Anderson JL, Pirmohamed M, Klein TE, Limdi NA, Cavallari LH, Wadelius M: Clinical pharmacogenetics implementation consortium (cpic) guideline for pharmacogenetics-guided warfarin dosing: 2017 update. Clin Pharmacol Ther. 2017 Feb 15. doi: 10.1002/cpt.668. [Article]