Pharmacogenomic Effect/ADR for Sevoflurane (DBSNPE000278)

Identifier
DBSNPE000278, DBSNPE000279, DBSNPE000280, DBSNPE000281, DBSNPE000282, DBSNPE000283, DBSNPE000284, DBSNPE000285, DBSNPE000286, DBSNPE000287, DBSNPE000288, DBSNPE000289, DBSNPE000290, DBSNPE000291, DBSNPE000292, DBSNPE000293, DBSNPE000294, DBSNPE000295, DBSNPE000296, DBSNPE000297, DBSNPE000298, DBSNPE000299, DBSNPE000300, DBSNPE000301, DBSNPE000302, DBSNPE000303, DBSNPE000304, DBSNPE000305, DBSNPE000306, DBSNPE000307, DBSNPE000308, DBSNPE000309, DBSNPE000310, DBSNPE000311, DBSNPE000312
Drug
Sevoflurane (DB01236)
Interacting Gene/Enzyme
Ryanodine receptor 1
Gene Name
RYR1
UniProt ID
P21817
Defining Change(s)
c.103T>Crs193922747
c.487C>Trs118192161
c.488G>Trs193922753
c.742G>Ars1801086
c.742G>Crs1801086
c.1021G>Ars121918592
c.1209C>Grs118192116
c.1565A>Crs118192162
c.1589G>ANot Available
c.1654C>Trs193922770
c.1840C>Trs118192172
c.1841G>Trs193922772
c.6487C>Trs118192175
c.6488G>Ars118192163
c.6502G>Ars118192176
c.6617C>Grs118192177
c.6617C>Trs118192177
c.7007G>ANot Available
c.7048G>Ars193922802
c.7124G>Crs193922807
c.7282G>Ars193922809
c.7300G>Ars121918593
c.7304G>Ars28933396
c.7360C>Trs193922816
c.7361G>Ars118192122
c.7372C>Trs28933397
c.7373G>Ars121918594
c.7522C>Trs118192178
c.7523G>ANot Available
c.14387A>Grs118192167
c.14477C>Trs121918595
c.14497C>TNot Available
c.14512C>Grs193922878
c.14582G>Ars63749869
c.14693T>Crs118192170
Allele Name
Not Available
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Malignant hyperthermia vulnerability
Description
Malignant hyperthermia.
References
  1. UltaneĀ®(sevoflurane)[package insert]. North Chicago: Illinois: AbbVie Inc.; 2014. https://emhg.org/genetics/mutations-in-ryr1/ [Link]