Pharmacogenomic Effect/ADR for Pimozide (DBSNPE004758)

Identifier
DBSNPE004758
Drug
Pimozide (DB01100)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Not Available
Allele Name
CYP2D6*68B
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirement.
References
  1. OrapĀ® (Pimozide) tablets[package insert]. Sellersville, Pennsylvania: Teva Pharmaceuticals USA; 2011. [Link]