Pharmacogenomic Effect/ADR for Codeine (DBSNPE005452)
- Identifier
- DBSNPE005452
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
-1584C>G Not Available -1235A>G Not Available -740C>T Not Available -678G>A Not Available CYP2D7 gene conversion in intron 1 Not Available 1661G>C Not Available 2850C>T Not Available 3172A>C Not Available 4180G>C Not Available - Allele Name
- CYP2D6*51
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
- References
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [PubMed:24458010]