Pharmacogenomic Effect/ADR for Codeine (DBSNPE005461)
- Identifier
- DBSNPE005461
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
-1426C>T Not Available -1235A>G Not Available -1000G>A Not Available 100C>T Not Available 310G>T Not Available 843T>G Not Available 1039C>T Not Available 1661G>C Not Available 2097A>G Not Available 2927_2945delGATCCTACATCCGGATGTG Not Available 3384A>C Not Available 3582A>G Not Available 4180G>C Not Available 4401C>T Not Available - Allele Name
- CYP2D6*101
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. Lack of efficacy. For individual with two non-functional alleles, alternative drug recommended.
- References
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [Article]