Pharmacogenomic Effect/ADR for Codeine (DBSNPE005462)
- Identifier
- DBSNPE005462
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
Normal allele duplicated. Not Available - Allele Name
- CYP2D6*1XN
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred
- Groups
- Ultra-rapid metabolizer CYP2D6
- Description
- Ultra-rapid drug metabolizer. Risk of toxicity, alternative drug recommended.
- References
- Crews KR, Gaedigk A, Dunnenberger HM, Leeder JS, Klein TE, Caudle KE, Haidar CE, Shen DD, Callaghan JT, Sadhasivam S, Prows CA, Kharasch ED, Skaar TC: Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450 2D6 genotype and codeine therapy: 2014 update. Clin Pharmacol Ther. 2014 Apr;95(4):376-82. doi: 10.1038/clpt.2013.254. Epub 2014 Jan 23. [Article]