- Identifier
- DBSNPE005500
- Drug
- Amitriptyline (DB00321)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
- Allele Name
- CYP2D6*21
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects
- References
- Chida M, Yokoi T, Nemoto N, Inaba M, Kinoshita M, Kamataki T: A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype. Pharmacogenetics. 1999 Jun;9(3):287-93. [Article]
- Yamazaki H, Kiyotani K, Tsubuko S, Matsunaga M, Fujieda M, Saito T, Miura J, Kobayashi S, Kamataki T: Two novel haplotypes of CYP2D6 gene in a Japanese population. Drug Metab Pharmacokinet. 2003;18(4):269-71. [Article]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]