- Identifier
- DBSNPE005526
- Drug
- Acetylsalicylic acid (DB00945)
- Interacting Gene/Enzyme
- Cytochrome P450 2C9
- Gene Name
- CYP2C9
- UniProt ID
- P11712
- Defining Change(s)
- Allele Name
- CYP2C9*8
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Decreased CYP2C9
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Blaisdell J, Jorge-Nebert LF, Coulter S, Ferguson SS, Lee SJ, Chanas B, Xi T, Mohrenweiser H, Ghanayem B, Goldstein JA: Discovery of new potentially defective alleles of human CYP2C9. Pharmacogenetics. 2004 Aug;14(8):527-37. [Article]
- Allabi AC, Gala JL, Horsmans Y: CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population. Pharmacogenet Genomics. 2005 Nov;15(11):779-86. [Article]
- Liu Y, Jeong H, Takahashi H, Drozda K, Patel SR, Shapiro NL, Nutescu EA, Cavallari LH: Decreased warfarin clearance associated with the CYP2C9 R150H (*8) polymorphism. Clin Pharmacol Ther. 2012 Apr;91(4):660-5. doi: 10.1038/clpt.2011.269. Epub 2012 Feb 29. [Article]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]