- Identifier
- DBSNPE005532
- Drug
- Acetylsalicylic acid (DB00945)
- Interacting Gene/Enzyme
- Cytochrome P450 2C9
- Gene Name
- CYP2C9
- UniProt ID
- P11712
- Defining Change(s)
1075A>C | Not Available |
1190A>C | Not Available |
1425A>T | Not Available |
- Allele Name
- CYP2C9*18
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Decreased CYP2C9
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Zhao F, Loke C, Rankin SC, Guo JY, Lee HS, Wu TS, Tan T, Liu TC, Lu WL, Lim YT, Zhang Q, Goh BC, Lee SC: Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther. 2004 Sep;76(3):210-9. [Article]
- DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA: Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec;315(3):1085-90. Epub 2005 Aug 11. [Article]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]