Pharmacogenomic Effect/ADR for Clopidogrel (DBSNPE005601)

Identifier
DBSNPE005601
Drug
Clopidogrel (DB00758)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
1075A>CNot Available
1190A>CNot Available
1425A>TNot Available
Allele Name
CYP2C9*18
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Decreased CYP2C9
Description
Poor drug metabolizer, lower dose requirements, higher risk for drug-drug interactions
References
  1. Zhao F, Loke C, Rankin SC, Guo JY, Lee HS, Wu TS, Tan T, Liu TC, Lu WL, Lim YT, Zhang Q, Goh BC, Lee SC: Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther. 2004 Sep;76(3):210-9. [Article]
  2. DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA: Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec;315(3):1085-90. Epub 2005 Aug 11. [Article]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]