Pharmacogenomic Effect/ADR for Codeine (DBSNPE005626)

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Identifier
DBSNPE005626
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
137insT, 137_138insTNot Available
Allele Name
CYP2D6*15
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements
References
  1. Sachse C, Brockmoller J, Bauer S, Reum T, Roots I: A rare insertion of T226 in exon 1 of CYP2D6 causes a frameshift and is associated with the poor metabolizer phenotype: CYP2D6*15. Pharmacogenetics. 1996 Jun;6(3):269-72. [Article]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]