Pharmacogenomic Effect/ADR for Codeine (DBSNPE005630)
- Identifier
- DBSNPE005630
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
-1770G>A Not Available -1584C>G Not Available -1235A>G Not Available -740C>T Not Available -678G>A Not Available CYP2D7 gene conversion in intron 1 Not Available 310G>T Not Available 746C>G Not Available 843T>G Not Available 1661G>C Not Available 2850C>T Not Available 3384A>C Not Available 3584G>A Not Available 3790C>T Not Available 4042G>A Not Available 4180G>C Not Available 4481G>A Not Available - Allele Name
- CYP2D6*31
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Marez D, Legrand M, Sabbagh N, Lo Guidice JM, Spire C, Lafitte JJ, Meyer UA, Broly F: Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution. Pharmacogenetics. 1997 Jun;7(3):193-202. [PubMed:9241659]
- Allorge D, Breant D, Harlow J, Chowdry J, Lo-Guidice JM, Chevalier D, Cauffiez C, Lhermitte M, Blaney FE, Tucker GT, Broly F, Ellis SW: Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins. 2005 May 1;59(2):339-46. [PubMed:15726636]
- Gaedigk A, Isidoro-Garcia M, Pearce RE, Sanchez S, Garcia-Solaesa V, Lorenzo-Romo C, Gonzalez-Tejera G, Corey S: Discovery of the nonfunctional CYP2D6 31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep;66(9):859-64. doi: 10.1007/s00228-010-0831-4. Epub 2010 May 16. [PubMed:20473659]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]