Pharmacogenomic Effect/ADR for Codeine (DBSNPE005633)
- Identifier
- DBSNPE005633
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
1863_1864ins(TTT CGC CCC)2 rs72549356 - Allele Name
- CYP2D6*40
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Gaedigk A, Bradford LD, Marcucci KA, Leeder JS: Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther. 2002 Jul;72(1):76-89. [PubMed:12152006]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]