Pharmacogenomic Effect/ADR for Codeine (DBSNPE005634)

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Identifier
DBSNPE005634
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
3259_3260insGTrs72549346
Allele Name
CYP2D6*42
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements
References
  1. Gaedigk A, Ndjountche L, Gaedigk R, Leeder JS, Bradford LD: Discovery of a novel nonfunctional cytochrome P450 2D6 allele, CYP2D642, in African American subjects. Clin Pharmacol Ther. 2003 Jun;73(6):575-6. [PubMed:12811367]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]