Pharmacogenomic Effect/ADR for Codeine (DBSNPE005639)
- Identifier
- DBSNPE005639
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
100C>T Not Available 310G>T Not Available 843T>G Not Available 887C>T Not Available 1039C>T Not Available 1661G>C Not Available 3384A>C Not Available 3582A>G Not Available gene conversion to CYP2D7 in exon 9 Not Available 4180G>C Not Available - Allele Name
- CYP2D6*57
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Soyama A, Kubo T, Miyajima A, Saito Y, Shiseki K, Komamura K, Ueno K, Kamakura S, Kitakaze M, Tomoike H, Ozawa S, Sawada J: Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene. Drug Metab Pharmacokinet. 2004 Aug;19(4):313-9. [Article]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [Article]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]