Pharmacogenomic Effect/ADR for Codeine (DBSNPE005642)

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Identifier
DBSNPE005642
Drug
Codeine (DB00318)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Not Available
Allele Name
CYP2D6*68B
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer, lower dose requirements
References
  1. Gaedigk A, Twist GP, Leeder JS: CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics. 2012 Jan;13(1):91-111. doi: 10.2217/pgs.11.135. Epub 2011 Nov 23. [Article]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]