Pharmacogenomic Effect/ADR for Codeine (DBSNPE005642)
- Identifier
- DBSNPE005642
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4. Not Available - Allele Name
- CYP2D6*68B
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Gaedigk A, Twist GP, Leeder JS: CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics. 2012 Jan;13(1):91-111. doi: 10.2217/pgs.11.135. Epub 2011 Nov 23. [PubMed:22111604]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]