- Identifier
- DBSNPE005643
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
| 2988G>A | rs28371725 |
| -1426C>T | Not Available |
| -1235A>G | Not Available |
| -1000G>A | Not Available |
| 100C>T | Not Available |
| 310G>T | Not Available |
| 746C>G | Not Available |
| 843T>G | Not Available |
| 1062A>G | Not Available |
| 1661G>C | Not Available |
| 2850C>T | Not Available |
| 3384A>C | Not Available |
| 3584G>A | Not Available |
| 3790C>T | Not Available |
| 4180G>C | Not Available |
| 4401C>T | Not Available |
| 4481G>A | Not Available |
- Allele Name
- CYP2D6*69
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Gaedigk A, Frank D, Fuhr U: Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual. Eur J Clin Pharmacol. 2009 Jan;65(1):97-100. doi: 10.1007/s00228-008-0559-6. Epub 2008 Sep 17. [PubMed:18797858]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]