- Identifier
- DBSNPE005645
- Drug
- Codeine (DB00318)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
| -1426C>T | Not Available |
| -1235A>G | Not Available |
| -1109C>T | Not Available |
| -1000G>A | Not Available |
| 100C>T | Not Available |
| 310G>T | Not Available |
| 843T>G | Not Available |
| 1039C>T | Not Available |
| 1661G>C | Not Available |
| 2097A>G | Not Available |
| 2828delC | Not Available |
| 3384A>C | Not Available |
| 3582A>G | Not Available |
| 4180G>C | Not Available |
| 4401C>T | Not Available |
- Allele Name
- CYP2D6*100
- Genotype(s)
- Not Available
- Type(s)
- Effect Inferred
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer, lower dose requirements
- References
- Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]