Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE005783)

Identifier
DBSNPE005783
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
1297C>Trs56337013
Allele Name
CYP2C19*5
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C19
Description
Poor metabolizer, lower dose requirement
References
  1. Xiao ZS, Goldstein JA, Xie HG, Blaisdell J, Wang W, Jiang CH, Yan FX, He N, Huang SL, Xu ZH, Zhou HH: Differences in the incidence of the CYP2C19 polymorphism affecting the S-mephenytoin phenotype in Chinese Han and Bai populations and identification of a new rare CYP2C19 mutant allele. J Pharmacol Exp Ther. 1997 Apr;281(1):604-9. [Article]
  2. Ibeanu GC, Blaisdell J, Ghanayem BI, Beyeler C, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Daly AK, Goldstein JA: An additional defective allele, CYP2C19*5, contributes to the S-mephenytoin poor metabolizer phenotype in Caucasians. Pharmacogenetics. 1998 Apr;8(2):129-35. [Article]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]