Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE005785)

Identifier
DBSNPE005785
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
19294T>Ars72558186
Allele Name
CYP2C19*7
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C19
Description
Poor metabolizer, lower dose requirement
References
  1. Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S, Bouchardy C, Wilkinson GR, Dayer P, Goldstein JA: A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Ther. 1999 Aug;290(2):635-40. [Article]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]