Pharmacogenomic Effect/ADR for Mephenytoin (DBSNPE005786)

Identifier
DBSNPE005786
Drug
Mephenytoin (DB00532)
Interacting Gene/Enzyme
Cytochrome P450 2C19
Gene Name
CYP2C19
UniProt ID
P33261
Defining Change(s)
557G>Crs140278421
991A>GNot Available
Allele Name
CYP2C19*22
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2C19
Description
Poor metabolizer, lower dose requirement
References
  1. Takahashi M, Saito T, Ito M, Tsukada C, Katono Y, Hosono H, Maekawa M, Shimada M, Mano N, Oda A, Hirasawa N, Hiratsuka M: Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation. Pharmacogenomics J. 2015 Feb;15(1):26-32. doi: 10.1038/tpj.2014.30. Epub 2014 Jul 8. [Article]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]