- Identifier
- DBSNPE005988
- Drug
- Metoprolol (DB00264)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
- Allele Name
- CYP2D6*14A
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred
- Groups
- Non-functional CYP2D6
- Description
- Increased risk of slow heart rate (bradycardia)
- References
- Wang SL, Lai MD, Huang JD: G169R mutation diminishes the metabolic activity of CYP2D6 in Chinese. Drug Metab Dispos. 1999 Mar;27(3):385-8. [Article]
- Sakuyama K, Sasaki T, Ujiie S, Obata K, Mizugaki M, Ishikawa M, Hiratsuka M: Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57). Drug Metab Dispos. 2008 Dec;36(12):2460-7. doi: 10.1124/dmd.108.023242. Epub 2008 Sep 10. [Article]
- The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]