Pharmacogenomic Effect/ADR for Tioguanine (DBSNPE006067)
- Identifier
- DBSNPE006067
- Drug
- Tioguanine (DB00352)
- Interacting Gene/Enzyme
- Thiopurine S-methyltransferase
- Gene Name
- TPMT
- UniProt ID
- P51580
- Defining Change(s)
G Allele rs1800462 - Allele Name
- TPMT*2
- Genotype(s)
- (G;G) / (C;G)
- Type(s)
- ADR Directly Studied
- Groups
- Non-functional TPMT
- Description
- The presence of this polymorphism in TPMT may be associated with an increased risk of developing rapid bone marrow suppression when treated with tioguanine.
- References
- Relling MV, Gardner EE, Sandborn WJ, Schmiegelow K, Pui CH, Yee SW, Stein CM, Carrillo M, Evans WE, Klein TE: Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26. [Article]