Pharmacogenomic Effect/ADR for Tramadol (DBSNPE006626)

Identifier
DBSNPE006626
Drug
Tramadol (DB00193)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
1758G>Ars5030865
Allele Name
CYP2D6*14A
Genotype(s)
Not Available
Type(s)
ADR Inferred Effect
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
References
  1. UltramĀ® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]