Pharmacogenomic Effect/ADR for Tramadol (DBSNPE006634)
- Identifier
- DBSNPE006634
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
1863_1864ins(TTT CGC CCC)2 rs72549356 - Allele Name
- CYP2D6*40
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred Effect
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
- References
- Ultram® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]