Pharmacogenomic Effect/ADR for Tramadol (DBSNPE006638)

Identifier
DBSNPE006638
Drug
Tramadol (DB00193)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1584C>GNot Available
-1235A>GNot Available
-740C>TNot Available
-678G>ANot Available
CYP2D7 gene conversion in intron 1Not Available
1661G>CNot Available
2850C>TNot Available
3172A>CNot Available
4180G>CNot Available
Allele Name
CYP2D6*51
Genotype(s)
Not Available
Type(s)
ADR Inferred Effect
Groups
Non-functional CYP2D6
Description
Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
References
  1. UltramĀ® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]