Pharmacogenomic Effect/ADR for Tramadol (DBSNPE006643)
- Identifier
- DBSNPE006643
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4. Not Available - Allele Name
- CYP2D6*68B
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred Effect
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
- References
- Ultram® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]