Pharmacogenomic Effect/ADR for Tramadol (DBSNPE006647)
- Identifier
- DBSNPE006647
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
-1426C>T Not Available -1235A>G Not Available -1000G>A Not Available 100C>T Not Available 310G>T Not Available 843T>G Not Available 1039C>T Not Available 1661G>C Not Available 2097A>G Not Available 2927_2945delGATCCTACATCCGGATGTG Not Available 3384A>C Not Available 3582A>G Not Available 4180G>C Not Available 4401C>T Not Available - Allele Name
- CYP2D6*101
- Genotype(s)
- Not Available
- Type(s)
- ADR Inferred Effect
- Groups
- Non-functional CYP2D6
- Description
- Poor drug metabolizer. This results in reduced analgesic efficacy and decreased risk of opioid toxicity as well as increased risk of seizures and serotonin syndrome. Consider alternative therapies.
- References
- Ultram® (tramadol hydrochloride) tablets[package insert]. Titusville, New Jersey: Janssen Pharmaceuticals, Inc.; 2016. [Link]