Pharmacogenomic Effect/ADR for Phenprocoumon (DBSNPE007290)

Identifier
DBSNPE007290
Drug
Phenprocoumon (DB00946)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
374G>Ars72558189
Allele Name
CYP2C9*14
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Decreased CYP2C9
Description
Associated with delayed stabilization. If carrier of rs9934438 as well, increased risk of severe overanticoagulation.
References
  1. Zhao F, Loke C, Rankin SC, Guo JY, Lee HS, Wu TS, Tan T, Liu TC, Lu WL, Lim YT, Zhang Q, Goh BC, Lee SC: Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose. Clin Pharmacol Ther. 2004 Sep;76(3):210-9. [Article]
  2. DeLozier TC, Lee SC, Coulter SJ, Goh BC, Goldstein JA: Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians. J Pharmacol Exp Ther. 2005 Dec;315(3):1085-90. Epub 2005 Aug 11. [Article]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]