Pharmacogenomic Effect/ADR for Phenprocoumon (DBSNPE007294)

Identifier
DBSNPE007294
Drug
Phenprocoumon (DB00946)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
641A>TNot Available
Allele Name
CYP2C9*28
Genotype(s)
Not Available
Type(s)
ADR Inferred
Groups
Decreased CYP2C9
Description
Associated with delayed stabilization. If carrier of rs9934438 as well, increased risk of severe overanticoagulation.
References
  1. Maekawa K, Fukushima-Uesaka H, Tohkin M, Hasegawa R, Kajio H, Kuzuya N, Yasuda K, Kawamoto M, Kamatani N, Suzuki K, Yanagawa T, Saito Y, Sawada J: Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese. Pharmacogenet Genomics. 2006 Jul;16(7):497-514. [Article]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]