Pharmacogenomic Effect/ADR for Tramadol (DBSNPE007319)
- Identifier
- DBSNPE007319
- Drug
- Tramadol (DB00193)
- Interacting Gene/Enzyme
- Cytochrome P450 2D6
- Gene Name
- CYP2D6
- UniProt ID
- P10635
- Defining Change(s)
100C>T (but also appears in other variants) rs1065852 - Allele Name
- CYP2D6*10
- Genotype(s)
- Not Available
- Type(s)
- ADR pgx review
- Groups
- Not Available
- Description
- This mutation leads to an unstable CYP2D6 enzyme with lower metabolic activity.
- References
- Xu J, Zhang XC, Lv XQ, Xu YY, Wang GX, Jiang B, Cai L, Cai XJ: Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients. Pharmazie. 2014 Feb;69(2):138-41. [PubMed:24640604]