Pharmacogenomic Effect/ADR for Tramadol (DBSNPE007319)

Identifier
DBSNPE007319
Drug
Tramadol (DB00193)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
100C>T (but also appears in other variants)rs1065852
Allele Name
CYP2D6*10
Genotype(s)
Not Available
Type(s)
ADR pgx review
Groups
Not Available
Description
This mutation leads to an unstable CYP2D6 enzyme with lower metabolic activity.
References
  1. Xu J, Zhang XC, Lv XQ, Xu YY, Wang GX, Jiang B, Cai L, Cai XJ: Effect of the cytochrome P450 2D6*10 genotype on the pharmacokinetics of tramadol in post-operative patients. Pharmazie. 2014 Feb;69(2):138-41. [PubMed:24640604]