Pharmacogenomic Effect/ADR for Methadone (DBSNPE007327)

Identifier
DBSNPE007327
Drug
Methadone (DB00333)
Interacting Gene/Enzyme
Cytochrome P450 2B6
Gene Name
CYP2B6
UniProt ID
P20813
Defining Change(s)
c.*1355A > Grs707265
Allele Name
CYP2B6 3′UTR
Genotype(s)
Not Available
Type(s)
pgx review
Groups
Not Available
Description
The presence of the rs707265 allele (CYP2B6 c.*1355A>G) has been shown increase the [(S)-MTD/MTD Dose] plasma ratio, and reduce clearance of (S)-methadone.
References
  1. Ahmad T, Valentovic MA, Rankin GO: Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics. Biochem Pharmacol. 2018 Jul;153:196-204. doi: 10.1016/j.bcp.2018.02.020. Epub 2018 Feb 16. [Article]