Pharmacogenomic Effect/ADR for Methadone (DBSNPE007328)

Identifier
DBSNPE007328
Drug
Methadone (DB00333)
Interacting Gene/Enzyme
Cytochrome P450 2B6
Gene Name
CYP2B6
UniProt ID
P20813
Defining Change(s)
c.*1277A > Trs1038376
Allele Name
CYP2B6 3′UTR
Genotype(s)
Not Available
Type(s)
pgx review
Groups
Not Available
Description
The presence of the rs1038376 allele (CYP2B6 c.*1277A > T) has been shown to increase the [(S)-MTD/MTD Dose] plasma ratio and reduce (S)-MTD clearance.
References
  1. Ahmad T, Valentovic MA, Rankin GO: Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics. Biochem Pharmacol. 2018 Jul;153:196-204. doi: 10.1016/j.bcp.2018.02.020. Epub 2018 Feb 16. [Article]