Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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Displaying entries 226 - 250 of 6330 in total

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
							Clear
Paroxetine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of paroxetine.	Details
Paroxetine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of paroxetine.	Details
Paroxetine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of paroxetine.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of fluvoxamine.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of fluvoxamine.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of fluvoxamine.	Details
Fluvoxamine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of fluvoxamine.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	ADR Directly Studied	Patients with this polymorphism in CYP2C19 are poor metabolizers of clopidogrel and are associated with diminished platelet response and increased risk of adverse cardiovascular events in response to clopidogrel therapy.	Details
Clopidogrel	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Directly Studied Effect	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of clopidogrel.	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*2	Not Available	681G>A (rs4244285)	Directly Studied Effect	The presence of this polymorphism in CYP2C19 is associated with poor metabolism of voriconazole.	Details
Voriconazole	Cytochrome P450 2C19 Gene symbol: CYP2C19 UniProt: P33261	CYP2C19*3	Not Available	636G>A (rs4986893)	Directly Studied Effect	The presence of this polymorphism in CYP2C19 is associated with reduced or poor metabolism of voriconazole.	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of amitriptyline.	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of amitriptyline.	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of amitriptyline.	Details
Amitriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of amitriptyline.	Details
Nortriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.	Details
Nortriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.	Details
Nortriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.	Details
Nortriptyline	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of nortriptyline.	Details
Desipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of desipramine.	Details
Desipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of desipramine.	Details
Desipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*5	Not Available	Whole-gene deletion	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of desipramine.	Details
Desipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*6	Not Available	1707delT (rs5030655)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of desipramine.	Details
Clomipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*3	Not Available	2549delA (rs35742686)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of clomipramine.	Details
Clomipramine	Cytochrome P450 2D6 Gene symbol: CYP2D6 UniProt: P10635	CYP2D6*4	Not Available	A allele (rs3892097)	Effect Directly Studied	The presence of this polymorphism in CYP2D6 is associated with reduced or poor metabolism of clomipramine.	Details

Displaying entries 226 - 250 of 6330 in total

Pharmaco-genomicsPharmacogenomic Pharmacological Effects and Adverse Drug Reactions

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